The Saints will be hoping that their luck against the Reds is set to change in the New Year, as Southampton have lost each of their last six games to the champions.
Liverpool forward Mohamed Salah has been a big reason for those results, with the Egyptian scoring seven goals in his six league clashes against Southampton.
With a win on the south coast, Jurgen Klopp’s side would move three points clear at the top of the Premier League.
Here’s everything you need to know about the match:
When is it?
The fixture will kick-off at 8pm GMT at St Mary’s Stadium.
How can I watch it?
The match will be televised on Sky Sports Premier League and Sky Sports Main Event, with coverage from 7pm GMT. Subscribers can also stream the game live on the Sky Sports website and SkyGo app.
What is the team news?
Jurgen Klopp could recall Georginio Wijnaldum to the side after he was rested at Newcastle, while Thiago could make just his second league start of the season. Nat Phillips will likely keep his place alongside Fabinho with Joel Matip out.
Southampton: Forster, Walker-Peters, Bednarek, Stephens, Bertrand, Armstrong, Ward-Prowse, Romeu, Walcott, Adams, Ings
Liverpool: Alisson, Alexander-Arnold, Phillips, Fabinho, Robertson, Thiago, Henderson, Wijnaldum, Salah, Firmino, Mane
Southampton are a dangerous outfit, proving that they can step up and threaten teams. Liverpool will be wary though, and with Thiago finding form and Manchester United applying pressure, I think the Reds will find a way to win their first Premier League game of 2021. Southampton 0-2 Liverpool.