Brendan Rodgers’ side go in as the clear favourites, finishing top of their group to get to this stage, but could yet continue to rotate in this competition at this early stage.
The Foxes will have to juggle their European commitments with their form in the Premier League, as they currently sit third in the table, with goal difference the deciding factor between them and second placed Manchester United.
Slavia are comfortable at the top of the Czech league, and are on course to win it again, sitting 10 points above city rivals Sparta Prague, having won eight of their last nine league matches.
They are also particularly strong in their Sinobo Stadium, having won all their home matches in a tough group, which included Nice and Hapoel Be’er Sheva, so Leicester will need to be wary in this first leg. That said, Slavia did only qualify second in their group behind Bayer Leverkusen, who comfortably beat them away 4-0.
When is the match?
The game kicks off at 5:55pm on Thursday 18 February.
Where can I watch it?
The match will be shown live on BT Sport ESPN HD on TV. The match is also available to live stream on the BT Sport app.
What is the team news?
Leicester has a number of injuries, with James Justin, Timothy Castagne and Wesley Fofana all unfit for this game.
Losing Justin may have been a huge blow for the side, but Caglar Soyuncu being back in defence will hopefully make up for it.
Rodgers is likely to rest duo Wilfred Ndidi and Jamie Vardy after their recent returns from injury and could replace them with Nampalys Mendy and Kelechi Iheanacho.
Jindrich Trpisovsky is likely to field an unchanged team for this contest, following their 3-0 victory over Pardubice on Saturday.
Jan Kuchta netted two in that match to tally nine goals from only six appearances and is likely to be joined in the Leicester tie with Adballah Sima. He has scored three from four starts in Europe, and the duo could be a real danger for the Foxes.
Predicted line ups
Slavia Prague: Kolar, Bah, Kudela, Deli, Dorley, Holes, Provod, Sima, Stanciu, Olayinka, Kuchta.
Leicester: Schmeichel, Amartey, Evans, Soyuncu, Fuchs, Mendy, Tielemans, Under, Perez, Barnes, Iheanacho.
Slavia Prague – 11/2
Draw – 7/2
Leicester – 10/3
Even with a changed line-up, Leicester should come away from the game with a positive result and be overwhelming favourites to reach the next round after the second leg. Slavia 1-2 Leicester.