The Blues are in fine form and advanced to the quarter-finals of the Champions League after defeating Atletico Madrid in each leg.
They secured a favourable draw for the next round too, as Chelsea will face Porto.
Meanwhile, Sheffield United are desperate for a positive result as the FA Cup is their last opportunity to add some gloss to a dismal domestic campaign.
Here’s everything you need to know about the match.
When is it?
The fixture will kick-off at 1:30pm GMT at Stamford Bridge.
How can I watch it?
The match is live on BBC One with coverage starting from 1:15pm GMT. The match can also be streamed online via the BBC Sport website or BBC iPlayer.
What is the team news?
Thiago Silva is almost ready after recovering from a thigh issue but won’t be risked against the Blades. Tammy Abraham could return after an ankle problem, while Mason Mount and Jorginho are available.
David McGoldrick could be available after missing the 5-0 loss to Leicester with a knee injury. Jack O’Connell (knee), John Egan (toe), Jack Robinson (foot), Jack Rodwell and Sander Berge (both hamstring) are out.
Chelsea: Kepa, Azpilicueta, Christensen, Zouma, Hudson-Odoi, Jorginho, Gilmour, Chilwell, Pulisic, Giroud, Mount
Sheffield United: Ramsdale, Basham, Bryan, Stevens, Baldock, Lundstram, Norwood, Fleck, Lowe, McGoldrick, Sharp
Sheffield United: 12/1
Sheffield United have had a torrid year, and the FA Cup has given the club something to cheer during their poor league campaign. However, their run ends here – Chelsea are a different beast under Tuchel and are in great form. 2-0 Chelsea.