Three points against the Gunners could allow West Ham to dream of European football next season, while Arsenal themselves will need to recover after a dismal performance in the second leg of their Europa League tie with Olympiakos.
Here is everything you need to know:
When is it?
The fixture will kick-off at 3pm at the London Stadium.
How can I watch it?
The match is live on Sky Sports Premier League and Main Event with coverage starting from 2:30pm.
If you’re not a Sky customer you can grab a NOWTV Day Pass here to watch without a subscription.
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What is the team news?
Jesse Lingard will return for West Ham after missing the trip to Old Trafford as he is unable to face his parent club. Pablo Fornals is unlikely to play, joining Angelo Ogbonna, Arthur Masuaku and Andriy Yarmolenko in missing out.
Bukayo Saka faces a fitness test due to a hamstring issue, while Willian missed the Europa League clash on Thursday due to a calf problem. The Brazilian is unlikely to feature.
West Ham: Fabianski, Coufal, Diop, Dawson, Cresswell, Johnson, Rice, Soucek, Bowen, Lingard, Antonio
Arsenal: Leno, Bellerin, Luiz, Gabriel, Tierney, Partey, Xhaka, Pepe, Odegaard, Smith Rowe, Aubameyang
West Ham: 2/1
Both teams will feel that they can come away with all three points, so this Premier League fixture could be open. In the end, Arsenal’s inconsistent form will mean that nobody leaves with maximum points. 2-2 draw.